AwareofAware

DNA: the elephant in the lab – help needed!

So this is what I have been up to for what seems like forever, but is actually only about 15 months. I know it’s not NDE related per se, however, it is directly relevant to the fundamental question of whether or not life is just a material thing. So it is in fact very relevant to the question of whether or not there is more to life than just eating, breeding and dying. This is also the question we look at with NDEs being evidence for the existence of a conscious that is not bound to the material realm. It does tie in…honest!

Anyway, I was “inspired” to write this after seeing the Governor General of Canada ridicule people who believe that life wasn’t the result of random processes (you tube link). This is a subject that I have some expertise in from my Ph.D. in organic medicinal chemistry where I messed around with nucleosides and amino acids, and my subsequent career in clinical research which involved drugs that affect DNA replication. I have also followed the literature on the origin of life over the years and read a number of books on the subject, but most of them are deathly boring…I have tried to break that trend and inject a bit of “life” into the subject. Apparently, according to one of my editors and my graphic designer, I have succeeded, and this is where you, my forum friends and lurkers can give me a massive helping hand.

• Firstly, please buy a copy (I make about US$1.30 per copy whether it is paperback ($9.99 or ebook $2.99) – at worst, even if you don’t enjoy it, look at it as a donation for all the work I have done on this forum J . The ebook is available on Kindle, Kobo and most other ereaders in major markets (US, UK, Canada EU etc…it should even come to ibooks before too long as well). The paperback is more costly as it is print on demand, so the per unit production is the majority of the price. It is available at Amazon globally, and should be available in all other major on-line book stores within the next few days.
• Secondly, if you buy it and enjoy it please please recommend it to all your friends through social media and write a positive review on the platform from which you bought it, giving some details as to why you enjoyed it. Without this it will flop and all the time and money that I have put into it will be for nothing…but more importantly, the truth about our origins will remain buried under the layers of fake news and misinformation that is propagated on this subject by the media and even scientists (examples given). If you hate it, PM me through the contact page as to why…please don’t post a nasty review…it may kill it. Likewise, if you find an error, please PM me.

Lastly the name…yes that is my real name on the cover, Ben Williams was the main protagonist in a novel I wrote years ago called Deadly Medicine. I have mentioned before that Ben is not my real name…so I’m sorry if you missed that and are disappointed that my real name is Orson Wedgwood. It may be that because of another blog I have set up, I may need to change my posting name here to Orson.

On that last point. This blog is about NDEs and specifically research into NDEs. It will remain that, and in fact I will become more active again as time goes by as I already have a working draft for a book that I will be writing on the subject. That working draft is Aware of Aware, but it is a bit rubbish and needs updating…when that is complete many of the regular contributors on here may recognize some of the things they have said since they help inform me and others. With that in mind…get me motivated to get on with that…buy a copy of DNA: the elephant in the lab and make me feel appreciated!

Links to the book at amazon.com are below but searching for “DNA elephant in the lab” on any  book retailer globally, including your local amazon market, should work as well:

amazon US paperback link

amazon US kindle link

Thank you reading this far, and apologies if it was off topic…there will be one more post on this in a few weeks time, but otherwise, back to NDEs!!!

Why all this is so important

Apologies for not taking part in the discussions of late but the reasons will become apparent as you read on.

As regulars of this blog will know, my father had been suffering from Alzheimer’s for a number of years, and that in itself poses questions that we have discussed on here regarding what happens to the conscious person during the slow decaying of the brain. What happens to the memories…are they lost forever or stored in some “central repository” outside of this dimension? Of course we have absolutely no idea other than some of the insights that have been gleaned from various subjective NDE reports over the years. Which brings me on to a very personal NDE report, very close to home.

Usually we focus on the science of NDEs and what evidence we have either way, but today I am going to tell you about the NDE that first got me interested in this subject when I was 13 years old. My father was an honest man. He hated lying, and other than Santa, as far as I know he never lied to me about anything, which makes his NDE account the one that holds the most validity to me. He told me that when he was about 9 years old he got knocked off his bike by a car. Suddenly he was above the scene watching people running towards the boy sprawled on the ground in front of the car. The next thing he remembered was being in a beautiful field. It was warm, and the colors were magically vibrant, and there were flowers like he had never seen. At the end of the field was a brilliant figure in white with his arms open. He was drawn towards the figure, but before he reached him (or her), he was suddenly back in his body and awake.

Last week my father passed on…to a better place. I can say that with absolute confidence, not just because of my personal faith but because of his and countless other NDE reports that have so much consistency in terms of fundamental content, that I do not need the results of AWARE II to believe that they are real. I am certain that our inner beings survive death and enter an eternal place of incomparable beauty, and into fellowship with others that is beyond any relationship we ever experience in this physical world.

Finally, the other reason that I have been “off the grid” is that in the little spare time I’ve had, I have been sorting out the internal design and cover of my book on the Origins of DNA and Life. It should be available next week, and of course I will let my friends on this forum know. You will also learn my real name as well (although I think some have already connected another blog with this, which I am just putting together, so may already know).

Brain damage and personality change: evidence against the existence of a separate soul?

Yesterday afternoon I was sitting in front of my father in his nursing home. He has advanced Alzheimer’s disease. He looks at me with his big sad brown eyes, and I know that he hasn’t got a clue who I am. He can’t speak, but he looks around curiously and he smiles…in fact oddly, he smiles more than he used to, and what I can say is that he is most definitely not the same “person” that I have known all my life. There are traces of the “person” but much of it has gone or changed, and yet he is still there, alive.

This kind of scenario is something I have thought about before with respect to NDEs and forms the basis of a legitimate objection to the belief that NDEs are evidence that the soul is separate from the brain (Chad bought this up once in one of our discussions). The argument goes something like this: if the soul is separate from the brain then when the brain is injured through trauma or disease the “personality” should not change as it is not a “function” of the brain. So this invites the question:

Are Personality and the Soul the same thing?

This is very important for trying to get to the bottom of this question, and to be honest it will not be covered fully in this post. I have actually moved countries recently, from Canada back to the UK, due to my parent’s poor health, and in the process I have changed jobs. I am now working in research in obesity (which is ironic as I am not slim!) and in particular on a drug that targets a receptor on a neuron in the hypothalamus which regulates appetite. I am therefore having to learn a lot more about neurotransmitters and how they affect behavior. People who have genetic defects that result in defects in the pathway I am working on, experience extreme hunger…all of the time, even after they have eaten. This then drives their behavior and the behaviors we observe are what we may perceive as personality…we make judgments, that person has no self-control.

Some people who have brain damage can become much angrier. Again, this affects our perception of their personality. Often they experience more extreme ranges of emotions, since emotions are often the result of hormone changes regulated in the brain. Much of this is what defines our personality, and it is absolutely, without doubt, the result of processes in our brain. But is it our soul? Are the soul and personality the same thing and if so, is the brain therefore producing our soul?

I have my thoughts on this, and one piece of anecdotal evidence that might help us understand this better is from NDE accounts. When people leave their bodies and look at themselves, they often “feel” nothing for the body. People often describe being in a peaceful or observant state as though emotions have all but disappeared. Not all though, as some report fear as well. However, in general people appear to be more “objective” in an NDE, as opposed to subjective when inside your body experiencing “life”. I’m not quite sure how, but I feel this may go some way towards answering the question about personality and soul.

I’d be interested in other’s thoughts on this as it is a really tricky question.

With regard to my father, I have tried to rationalize his situation to align with my beliefs. Specifically I believe that the destruction of large parts of his brain from a disease, has resulted in a massively reduced capacity of his soul to “interact” with his brain, resulting in some of the changes I see. Moreover, if some NDE reports are to be believed, then memory is not actually stored in the brain, but in some “central universal repository” and if this is the case, then perhaps my father’s ability to access that repository has gone. Of course, this is me squishing observations into my belief system, and I fully accept that this “understanding” is totally subjective.

Either way, brain damage causes carnage for those who suffer it and those who love them.

Evidence vs “Bullshit”

I promised I would address this particular publication in a new post, as it has got lost in a long and winding discussion that came out of the last post. Here is the link to the full text of the publication which was published in August this year:

Link to PDF of paper on Researchgate

And here is a link to the kind of media interpretation that this article invoked:

Wired – Turns out near-death experiences are psychedelic, not religious

Or the BBC

DMT trip feels like dying

The paper was written by a group of researchers from Imperial College London. Imperial is a premier research institution, so anything that comes out of it should be taken seriously even when it is published in Frontiers of Psychology, a less than premier journal. However, in spite of the source of the research, namely Imperial, the tone that at least one of the researchers adopts towards NDE experiences reveals a distinctly unscientific approach.

“But it’s bullshit. It’s classic pseudoscience,” says Robin Carhart-Harris, who designed the Psychedelic Research Group study with Chris.

This was a reference to Eben Alexander’s book and claims. Now I am not a wild fan of Alexander’s NDE account, and the publicity it generated, but to dismiss it as “bullshit” shows a chronic bias against the possibility that NDEs are a “supernatural” or genuinely religious phenomenon. If you start a research project with that assumption, then you are unlikely to draw unbiased conclusions.

To be fair, the paper itself does not read as badly as it might given the tone of the author in the interview. The study was designed to assess the similarity between the experience of taking the psychedelic drug DMT, with an NDE. To do this they used the Greyson scale, the scale devised by one of the fathers of NDE research, which includes 15 different elements most commonly associated with NDEs. These include tunnels, bright light OBE etc etc. They assessed how much overlap there was in terms of level of experience and range. Their findings revealed that DMT induced an experience which bore similarities to an NDE, with significant overlap on Greyson scores compared to previously published data on those who had experienced actual NDEs. There were a few exceptions, such as less reported life reviews, no point of no return etc, but in general many of the elements of NDEs were reported by subjects taking DMT.

While the original paper does not go so far as to say that this proves that NDEs are hallucinations induced by the release of various hormones and neurotransmitters in the brain at the time of dying, this is most definitely the tone adopted by the Wired article, and certainly appears to be what at least one of the authors believes.

I view things differently. While it is obvious there are some similarities between the two experiences, there are some important differences, some of which I briefly alluded to above. The lack of the kind of detailed life reviews that NDE experiencers report when compared with these DMT induced experiences is significant. If someone is about to potentially die, and a life review is a part of that process, then it makes sense that someone who is not close to death would not have one. This in some ways, using a bit of twisted logic, provides a bit of validation of the fact that NDEs are real. But you could only draw that conclusion if you viewed the research produced by this group through the biased lens that we believers view things.

The truth is, that you could interpret the data from this study in two completely different ways according to your own world view, and both interpretations would be consistent with the findings of the study.

As a reminder, the essence of the key finding was that taking DMT induces an experience which has significant similarity to an NDE.

The first way you could interpret this data is the way in which Wired magazine and the author have – namely that due to this similarity, this shows that NDEs are just a psychedelic experience produced entirely by the chemical activity of the brain.

The other way that that the data could be interpreted is that DMT disrupts the “anchoring” mechanism of the consciousness to the brain, and thereby causes temporary erratic separations of the conscious from the physical brain, but while the patient is alive and fully technically conscious. Here is a quote from one of the subjects:

“It’s probably the most intense experience I’ve had,” says Iona. “[The sense that] birth and death were just a transformation rather than an end was something that felt true.”

It is entirely consistent with the data from the study to suggest that DMT could indeed cause just the kind of disruption that I describe above. If the brain is just a host of the conscious then pumping a brain full of a drug that is neurotoxic may indeed cause the association with the brain to loosen, and for that conscious to briefly dip into “other realms”. The researcher dismisses this idea out of hand, but provides no rationale for making that assertion.

Ultimately, the evidence from this study is valid, but the conclusions drawn by the researchers themselves in the interview and the media may indeed be “bullshit”, and entirely the result of atheistic bias. At the end of the day, the study, while intriguing, is a great big “nothing burger” in terms of providing evidence that NDEs are not a “supernatural” phenomenon.

The Illusive Dr Parnia Tweets

Thanks to one of the regular contributors for this reminder, but Dr Parnia tweeted for the first time in a very long time:

I use the word illusive since he doesn’t really clarify what this means. Is this AWARE II, surely not as that is well under way now. Are these sub-studies of AWARE II? Are they completely new studies, and if so how will they differ?

Anyway, hopefully we will learn more before long.

Emptiness

I came across this in my googling of NDE research, and I think it may have been mentioned in a previous chat (sorry for not calling out the person who mentioned it). Click on the link to access the pdf. It is free to download.

Meditation-Induced Near-Death Experiences: a 3-Year Longitudinal Study William Van Gordon et al.

This “paper” was published last month in the Mindfulness journal. Anything with that name in the title is going to be Buddhist, so I approach anything I read with the appropriate filters in place.

In summary the researchers recruit 12 advanced meditators who conduct a specific form of meditation which induces a “Near-Death” like state. The researcher calls the experiences that these meditators have MI-NDEs (meditation induced NDEs). These meditators practice at least one of these types of meditation a year as a normal part of their spiritual pursuits. For the study they are asked to complete a number of questionnaires after each MI-NDE session, including one that identifies components of NDEs as defined by the Greyson scale. Most frequenters to this site will be familiar with the scale, but for those that aren’t I have included it at the bottom of this post:

There are some other questionnaires more related to Buddhist beliefs, and one face to face interview conducted very soon after one of the MI-NDE sessions. The study was run over 3 years, with data collected from each participant each year. In addition “controls” were used, which included recording the same subjective output from non-MI-NDE meditation sessions.

Below is the key statement regarding the conclusions of the authors:

“Findings demonstrated that compared to the control conditions, the MI-NDE prompted significantly greater pre-post increases in NDE profundity, mystical experiences and non-attachment. Furthermore, participants demonstrated significant increases in NDE profundity across the 3-year study period.”

Now, I am not going to in anyway criticize Buddhist beliefs. Nor am I going to question the claims of people who practice Buddhist meditation that they have deep and profound spiritual experiences, which may indeed include out of body elements etc. If I believe that the conscious is a separate entity to the brain and that it is separated from the brain at death, then it makes sense that it may be possible under certain conditions to separate it during life too.

However, this paper has two major issues to me:

1. The experience described by the meditators does not sound like an NDE
2. There are some whopping design flaws that open it to ridicule by anyone with even the remotest understanding of how (not to) conduct a rigorous scientific study, and which relates to one of the issues I repeatedly mention with regard to blinding the investigators

Firstly, from a qualitative perspective, the experiences described by the meditators do not sound like classic NDEs. The word Emptiness is used a lot. While some NDEs do report emptiness, I believe a higher proportion of true NDEs describe different sensations which are more positive. Moreover there are no reports of specific verified OBEs, a crucial element to lending credibility to any study like this. They do describe spiritual elements and encounters with spiritual beings, but having read many NDEs, what these guys are taking about feels very different. I want to state again, that I am not doubting that they experienced something, but it was not a classic NDE in the sense that we know it. However, without more detail, it is hard to say for sure.

Now to my second point. This study has more holes than a sieve from a credibility perspective. The language used is very scientific, and creates the air of genuine academic research, but the reality is very different.

1. The main author is a practicing Buddhist. Fine. However, he selects the study subjects from a group of people that he knows. Yep, that is the end of all credibility straight away. I understand why he did this: if you put this out there for all-comers you will attract a multitude of crazies, but that doesn’t change the fact this introduces humungous bias into the study, and lots of opportunities to influence outcome.
2. Who conducts the interviews etc is not really discussed. Neither is how the data was “protected”. This is my potential beef with AWARE II. There needs to be blinding otherwise a study is open to accusations of bias, which leads to me point 3.
3. Look at the graph below. It represents the improvement in the quality of NDEs over the 3 year period. In the first year the Greyson score barely exceeds 7, suggesting that they were not very NDE-like at all, but in the third year we have scores exceeding the average NDE score of “true” NDEs. In fact these meditators are getting so good at it that they experience virtually all of the components in the Greyson scale, something that very few true NDErs ever do.

Now I don’t want to suggest that anything nefarious is going on, but this graph screams “something fishy is going on” to me. The author puts it down to practice makes perfect. Mmm. That would be fine if these guys weren’t already top of their game in meditating. They had on average over 30 years’ experience of meditating, and performed 3 MI-NDE type mediations a year. They should be able to meditate in the spiritual Olympics…if such a games existed. No. What that graph says to me is that either deliberately, or not, the meditators were getting feedback that influenced how they answered the questions. They were possibly “coached”, or prompted in how to more “accurately” describe their experiences.

For me the real result is the year 1 result, and given the other things I said, this study experiences emptiness when it comes to generating useful data with regard to validating NDEs, or indeed supporting the belief that NDEs can be induced by certain types of meditation.

The Greyson Scale

– Experiencing an altered state of time

– Experiencing accelerated thought processes

– Life review

– Sense of sudden understanding

– Feelings of peace

– Feeling of joy

– Feeling of cosmic oneness

– Seeing/feeling surrounded by light

– Having vivid sensations

– Extrasensory perception

– Experiencing visions

– Experiencing a sense of being out of physical body

– Experiencing a sense of an ‘otherworldly’ environment

– Experiencing a sense of a mystical entity

– Experiencing a sense of deceased/religious figures

– Experiencing a sense of a border or point of no return

Anyone having an “experience” can assess whether it is an NDE by assigning scores of 0-2 for the elements listed above. If an experiencer gives 0, then the element wasn’t present, if it’s 2 then definitely present. In general a score of <7 is not considered to be an NDE.

Get Paid To Study NDEs

Thanks to Samwise for posting this in the comments section of the last post. Again, I felt this was worth creating a seperate post out of since it is news about the AWARE study, and the last post was nearing a hundred comments, so time to move on.

The link below is for a new position as a research data associate at New York University School Of Medicine. The job description is clearly for someone to be working alongside the AWARE II study team as it references Sam Parnia and describes elements of the protocol that we are familiar with.

AWARE study position

They are looking for a graduate level employee, and someone who is either studying for a Ph.D. or who has relevant qualifications. When I first looked at it, I thought it was full time, but it would appear to be a bit of a zero hours type position, with variable hours, and on a temp basis. This ties in with a comment that David said, and that they may be looking to recruit a few people, so that they have someone “on call” at all times to attend the crash cart in the event of a CA. There are also a number of other duties which focus on the data processing side of things.

As I mentioned in the comments section, my one big concern about this is the lack of blinding that this position introduces into the study. If the same person who attends the CA, does the interview and processes the data, then this opens up any positive hits to accusations of potential cheating. It is in many ways a small detail as I am sure there will be other ways of verifying the validity of any confirmed OBEs, but my preference would be to remove any possibility of the interviewer knowing what image was projected. It may be that this is indeed the case, but without seeing a copy of the full protocol it is impossible to know for sure.

Anyway, this is all good in every other respect. This study is really ramping up by the looks of things, and is being taken very seriously. Roll on 2020.

Tin Foil Hat or Genuine Press Bias?

I am in the process of working on a review of the literature on evidence against NDEs being a genuine out of body phenomenon. The key piece of evidence relates to reports of brain activity after the heart has stopped. There have been reports in rats up to 30 seconds after death, and also in some human studies, but for now I want to highlight the reality of mainstream media reporting on this topic, and how utterly dishonest it can be.

Further down is a quote from the Independent newspaper in the UK discussing a 2017 publication by a group of Canadians that was discussed briefly in the comments section of my last post (Alan mentioned a Newsweek article that cited the same original piece of research). The background is that four patients on an ICU had life support withdrawn and their brain activity was monitored closely before and after cardiac arrest. One of the patients showed some delta wave EEG activity up to thirty minutes after the heart had stopped supplying oxygenated blood to the brain. (Delta wave NREM sleep is not associated with dreaming or conscious sleep, but rather is the deep sleep when the body is repairing itself). Here is the EEG data showing the anomaly:

It is notable that the signals are extremely low in intensity after “death” (the dashed line), and therefore even if they are real, are extremely unlikely to signify “conscious” neuronal activity of the type that would be required to generate complex NDEs and store the information. However, our delightful media have a different take:

The UK Independent quote:

“But tests showed that the patients’ brain appeared to keep working ”

And

“The doctors don’t know what the purpose of the activity might be, and caution against drawing too many conclusions from such a small sample. But they write that it is difficult to think the activity was the result of a mistake, given that all of the equipment appeared to be working fine.”  Link to article

What was actually said in the publication:

“An unexpected finding in the current work was that single bursts of delta wave activity persisted following ECG and ABP cessation for one patient. It is difficult to posit a physiological basis for this EEG activity given that it occurs after a prolonged loss of circulation. These waveform bursts could, therefore, be artefactual in nature, although an artefactual source could not be identified.”

And in the discussion section:

“Finally, we also encountered one case where EEG activity persisted beyond the cessation of ABP. Given that this was only observed in one case and it persisted well beyond the loss of circulation, we speculate that this activity could reflect a nonneuronal artefact.”

Can J Neurol Sci. 2017; 44: 139-145

The inference in the Independent is that this “unexplained” activity invites speculation that the brain is up to something after death, adding credence to the meme that NDEs are a natural phenomenon, however the actual publication suggests it is most likely an artifact. Most people don’t bother reading the original piece of research, so will finish this media article concluding that brain activity occurs long after death, and thereby possibly dismissing NDEs as having natural explanations.

Anyway, as mentioned I am going to do a review of current literature on this topic and provide a summary. I will also be looking to shed more light on the difference between death of brain activity and permanent cellular death. Please feel free to make suggestions for appropriate articles in a comment (Please note, if you are posting a comment for the first time on this blog it will not appear immediately to avoid SPAM, trolling and BOTs. Due to my workload, it may be a day or two before I review it.)